The Low Testosterone Problem

It’s no secret, that as we age us males are in continual decline with our Testosterone (T) levels. By age 50, we can have 15-220 % lower T levels than we did at age 30. This is why we see the emergence of prescription medications that address low T.

Below is a chart that shows the level of normal T that a male would expect to have at different ages. According to the Mayo Clinic, testosterone levels are at their highest during adolescence and early adulthood, with the decline starting at age 30.

testo-graph

Interestingly, there is additional research that points to a decline that is more rapid then it has been in past generations; meaning there could be other factors at play. Either way; trying to support T levels is of great interest.

Options for Raising Testosterone

Beyond exercise and good nutrition men can turn to either the prescription medications and or towards supplements. With the former many have benefitted, but there are concerns about side effects; primarily heart attack, but also with possibly raising the risk of cancer to hormone-sensitive tissues (like the prostate).

Because of this risk, many will try the supplements approach. The problem is that most of the supplements reported to raise T, have only done so in in vitro models. This is an important distinction because, many of these substances have low bio-availabilities that are not exposed in these experimental models, but in fact do show up when done in human testing. Therefore, the list of natural substances that work in humans is very short.

One of the more promising nutrients on this short-list is D-aspartic acid.

data-table

The study showed that 3grams per day resulted in an increase of T of about 42% at day 12.

Effects of D-aspartate on LH and Testosterone Release in Human Serum

D-Aspartic acid has studies in vitro, in animals, and in humans to show that it works.  Additionally, it raises T at al level that is within what we would call “safer.”(Again, when concerned with the risk to hormone-sensitive tissue.)

The Sweet Spot for a T Formulation

For us at 3Care we wanted to address low T for our practitioners, but to do it in a way that is both effective and safe. Here is the checklist we sought to satisfy

Raise T within levels that would get individuals over 40 back to normal levels. No excessive increases so as to not pose any danger to hormone-sensitive tissues

  D-aspartic acid raises T 42%; an amount within a fairly safe range.

Address deficiency

  Studies show that a significant number of people who have low T have low vitamin D levels

3.   Provide healthy aging, nutritional support for Hormone-sensitive tissue

  Lycopene has shown to have great utility as the preferred antioxidant by the prostate in fighting free radicals.

The result of this approach is the creation of the new 3Care Therapeutics product TestoRight -hormone balance and healthy aging for men.

TestoRight



References

Mayo Clinic 2012
The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Topo E, Soricelli A, D’Aniello A, Ronsini S, D’Aniello G.
Source
1Stazione Zoologica Anton Dohrn, 80121, Villa Comunale, 80121, N apoli, Italy.
Brain Res Rev. 2007 Feb;53(2):215-34. Epub 2006 Nov 21.
D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role.
D’Aniello A.
Laboratory of Neurobiology, Stazione Zoologica A Dohrn, Villa Comunale 1, 80121 Napoli, Italy. daniello@szn.it
Association Between Plasma 25-OH Vitamin D and Testosterone Levels in Men
Katharina Nimptsch; Elizabeth A. Platz; Walter C. Willett; Edward Giovannucci
Posted: 07/13/2012; Clin Endocrinol. 2012;77(1):106-112. © 2012 Blackwell Publishing
Endocrinol. 2012 Jan;166(1):77-85. doi: 10.1530/EJE-11-0743. Epub 2011 Nov 2.
Association of hypogonadism with vitamin D status: the European Male Ageing Study.
Lee DM, Tajar A, Pye SR, Boonen S, Vanderschueren D, Bouillon R, O’Neill TW, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS,Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Wu FC; EMAS study group.

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